期刊
PLANT PHYSIOLOGY
卷 179, 期 4, 页码 1876-1892出版社
OXFORD UNIV PRESS INC
DOI: 10.1104/pp.18.01258
关键词
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资金
- Department of Biotechnology, Ministry of Science and Technology (Ramalingaswami Fellowship)
- Department of Biotechnology, Ministry of Science and Technology (IYBA)
- Department of Biotechnology, Ministry of Science and Technology (DBT) [BT/PR19193/BPA/118/195/2016]
- DST, Science and Engineering Research Board, Government of India [EMR/2016/000181]
- UGC, Government of India
- DBT, Government of India
- MHRD-HTRA, Government of India
- DBT-BIOCARE Women Scientist Program
- Science and Engineering Research Board early career research funding [ECR/2016/001176]
- European Research Council (ERC-StG miPDesign) [336295]
- Independent Research Fund Denmark (DFF-FNU, Adaptogenomics)
- NovoNordisk Foundation [NNF18OC0034226]
- European Research Council (ERC) [336295] Funding Source: European Research Council (ERC)
The bZIP transcription factor ELONGATED HYPOCOTYL5 (HY5) represents a major hub in the light-signaling cascade both under visible and UV-B light. The mode of transcriptional regulation of HY5, especially under UV-B light, is not well characterized. B-BOX (BBX) transcription factors regulate HY5 transcription and also posttranscriptionally modulate HY5 to control photomorphogenesis under white light. Here, we identify BBX31 as a key signaling intermediate in visible and UV-B light signal transduction in Arabidopsis (Arabidopsis thaliana). BBX31 expression is induced by UV-B radiation in a fluence-dependent manner. HY5 directly binds to the promoter of BBX31 and regulates its transcript levels. Loss- and gain-of-function mutants of BBX31 indicate that it acts as a negative regulator of photomorphogenesis under white light but is a positive regulator of UV-B signaling. Genetic interaction studies suggest that BBX31 regulates photomorphogenesis independent of HY5. We found no evidence for a direct BBX31-HY5 interaction, and they primarily regulate different sets of genes in white light. Under high doses of UV-B radiation, BBX31 promotes the accumulation of UV-protective flavonoids and phenolic compounds. It enhances tolerance to UV-B radiation by regulating genes involved in photoprotection and DNA repair in a HY5-dependent manner. Under UV-B radiation, overexpression of BBX31 enhances HY5 transcriptional levels in a UV RESISTANCE LOCUS8-dependent manner, suggesting that BBX31 might regulate HY5 transcription.
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