期刊
PIGMENT CELL & MELANOMA RESEARCH
卷 32, 期 4, 页码 593-600出版社
WILEY
DOI: 10.1111/pcmr.12770
关键词
histopathology; melanoma; sex; skin awareness; survival
资金
- Division of Cancer Prevention, National Cancer Institute [PO1 CA 42101]
We evaluated clinical, phenotypic, behavioral, and histopathologic variables in relationship to melanoma-specific survival by age at diagnosis among 650 populationbased melanoma patients in Connecticut, with 20 years of follow-up. Only one variable, skin awareness, was significantly associated with melanoma mortality in both groups. The variables that differed between the age-groups were anatomic site, Breslow thickness, histologic subtype, mitoses, tumor-infiltrating lymphocytes (TILs), and solar elastosis. Head and neck melanoma, Breslow thickness, nodular melanoma, and solar elastosis were all significantly more likely to be associated with mortality among the older subjects; among the younger subjects, the presence of mitoses was associated with an increased probability of dying and TILs were associated with a reduced risk of mortality.
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