期刊
PHYTOMEDICINE
卷 61, 期 -, 页码 -出版社
ELSEVIER GMBH
DOI: 10.1016/j.phymed.2019.152862
关键词
Ginsenoside Rh-2; CDDP-induced acute kidney injury; Caspase; Anti-apoptosis; Serum metabolomics
资金
- Jilin Science & Technology Development Plan [201603033YY]
- Yanbian Science & Technology Development Plan [2015NS14]
- Talents Team Major Program of Jilin Province of China (JRCBTZ. [2016]) [3]
Background: Ginsenoside Rh-2 (Rh-2), an important ingredient from Panax ginseng, has received much attention due to a range of pharmacological actions. Purpose: The aim of the study was to investigate the therapeutic potential Rh-2 on cisplatin (CDDP)-induced nephrotoxicity and to elucidate involved mechanisms. Study design: An in vivo mice model of CDDP-induced nephrotoxicity was established by a single intraperitoneal injection of CDDP (20 mg/kg) to assess the effects of Rh-2 on renal biochemical parameter, oxidative stress, inflammation tubular cell apoptosis and serum metabolic profiles. Results: Rh-2 protected against CDDP-induced renal dysfunction and ameliorated CDDP-induced oxidative stress, histopathological damage, inflammation and tubular cell apoptosis in kidney. Rh-2 treatment had significantly increased expression of Bcl-2 and decreased expression of p53, Bax, cytochrome c, caspase-8, caspase-9, and caspase-3 in kidney tissues. Metabolomic analysis identified 29 altered serum metabolites in Rh-2 treatment mice. Conclusion: These results suggest that Rh-2 protects against CDDP-induced nephrotoxicity via action on caspase-mediated pathway.
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