期刊
PHYTOMEDICINE
卷 54, 期 -, 页码 240-247出版社
ELSEVIER GMBH
DOI: 10.1016/j.phymed.2018.10.031
关键词
Salidroside; Diabetic nephropathy; Sirt1; PGC-1 alpha; Mitochondrial biogenesis
资金
- National Key Research and Development Program of China [2017YFA0701304]
- National Natural Science Foundation of China [81471037, 81770841]
- Project of Six Kinds of Talents Summit of Jiangsu Province [SWYY-051]
- Health and Family Planning Commission research projects of Jiangsu [H201522]
- Science and Technology Foundation of Nantong [BK2013006]
- Dr. Scientific Research Foundation of Nantong University, Jiangsu Province, China [14B40]
Background: Salidroside, an active component from Traditional Chinese Medicine Rhodiola rosea L., has various pharmacological functions including anti-inflammatory, anti-cancer and anti-oxidative properties. However, whether salidroside plays a beneficial role in diabetic nephropathy is still unclear. Purpose: The objective of this work was to investigate the potential roles of salidroside against diabetic nephropathy and the underlying molecular mechanisms. Methods: Streptozocin was given to obese mice to generate diabetic nephropathy animal model. Salidroside was administered to these mice and proteinuria, podocyte integrity, renal morphology and fibrosis, mitochondrial biogenesis were examined. Results: Our results showed that salidroside treatment greatly attenuates diabetic nephropathy as evidenced by decreased urinary albumin, blood urea nitrogen and serum creatinine. Morphological analysis indicated that salidroside improves renal structures in diabetic nephropathy. The decreases in nephrin and podocin expression were markedly reversed by salidroside. Moreover, kidney fibrosis in diabetic nephropathy mice was largely prevented by salidroside. Mechanistically, in salidroside-treated mice, the mitochondrial DNA copy and electron transport chain proteins were significantly enhanced. Meanwhile, the reduced Sirt1 and PGC-1 alpha expression in diabetic nephropathy was almost completely counteracted in the presence of salidroside. Conclusions: Our data showed that salidroside plays a beneficial role against diabetic nephropathy in mice, which probably via Sirt1/PGC-1 alpha mediated mitochondrial biogenesis.
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