期刊
PHYTOCHEMISTRY LETTERS
卷 29, 期 -, 页码 1-5出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.phytol.2018.10.014
关键词
Aspergillus sp.; Mangrove; Endophyte; Prenylated benzaldehyde; Pyridazine; Antiproliferative activity
资金
- Egyptian Science and Technology Development Funds (STDF) [5251]
Chemical investigation of the mangrove-derived fungus Aspergillus sp. AV-2 following fermentation on solid rice medium led to the isolation of a new phenyl pyridazine derivative (1) and a new prenylated benzaldehyde derivative, dioxoauroglaucin (2), together with fourteen known compounds (3-16). Chemical structures of the new compounds were unambiguously determined based on HRESIMS and extensive 1D and 2D NMR spectroscopic analyses. Compounds 2-7, 8 and 13 were assessed for their antiproliferative activity against Caco-2 cell lines, where flavoglaucin (6) revealed the most potent cytotoxicity with IC50 of 2.87 mu M.
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