期刊
PHYSICS OF FLUIDS
卷 31, 期 3, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.5081451
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资金
- National Institutes of Health [NIH] [R03EB014860]
- National Institute of Neurological Disorders and Stroke [NINDS] [R03NS090193]
- Center of Computational Research (CCR) of University at Buffalo
- Texas A&M High Performance Research Computing (HPRC)
A simple parameter, called the Aneurysm number (An) which is defined as the ratio of transport to vortex time scales, has been shown to classify the flow mode in simplified aneurysm geometries. Our objective is to test the hypothesis that An can classify the flow in patient-specific intracranial aneurysms (IA). Therefore, the definition of this parameter is extended to anatomic geometries by using hydraulic diameter and the length of expansion area in the approximate direction of the flow. The hypothesis is tested using image-based flow simulations in five sidewall and four bifurcation geometries, i.e., if An less than or similar to 1 (shorter transport time scale), then the fluid is transported across the neck before the vortex could be formed, creating a quasi-stationary shear layer (cavity mode). By contrast, if An greater than or similar to 1 (shorter vortex time scale), a vortex is formed. The results show that if An switches from An less than or similar to 1 to An greater than or similar to 1, then the flow mode switches from the cavity mode to the vortex mode. However, if An does not switch, then the IAs stay in the same mode. It is also shown that IAs in the cavity mode have significantly lower An, temporal fluctuations of wall shear stress and oscillatory shear index (OSI) compared to the vortex mode (p < 0.01). In addition, OSI correlates with An in each flow mode and with pulsatiity index in each IA. This suggests An to be a viable hemodynamic parameter which can be easily calculated without the need for detailed flow measurements/ simulations. Published under license by AIP Publishing.
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