期刊
PEDIATRIC DIABETES
卷 20, 期 6, 页码 693-701出版社
WILEY
DOI: 10.1111/pedi.12846
关键词
abdominal obesity; diabetes mellitus; dyslipidemia; hypertension; metabolic syndrome
资金
- NCATS NIH HHS [UL1 TR001425, UL1 TR000077, UL1 TR000154, UL1 TR000062, UL1 TR000423, UL1 Tr001450, UL1 TR002319] Funding Source: Medline
- NIDDK NIH HHS [UC4 DK108173, P30 DK057516] Funding Source: Medline
- NIH HHS [P30 DK57516, 1UC4DK108173, UL1 TR00423] Funding Source: Medline
- ACL HHS [U18DP006139, U18DP006138, U18DP006136, U18DP006131, U18DP006133, U18DP006134] Funding Source: Medline
- CDC HHS [U48/CCU919219, U18DP000247-06A1, U58/CCU019235-4, 1U18DP002709, U48/CCU419249, U18DP002714, U18DP002710-01, DP-10-001, U48/CCU519239, U48/CCU819241-3, 200-2010-35171, U18DP002708, 00097, DP-05-069, 1U18DP006131] Funding Source: Medline
- NCCDPHP CDC HHS [U01 DP000244, U18 DP006138, U01 DP000248, U18 DP006139, U01 DP000254, U01 DP000250, U01 DP000247, U18 DP002710, U18 DP002714, U18 DP002709, U18 DP002708, U01 DP000246] Funding Source: Medline
Background Given diabetes is an important risk factor for cardiovascular disease (CVD), we examined temporal trends in CVD risk factors by comparing youth recently diagnosed with type 1 diabetes (T1D) and type 2 diabetes (T2D) from 2002 through 2012. Methods The SEARCH for Diabetes in Youth Study identified youth with diagnosed T1D (n = 3954) and T2D (n = 706) from 2002 to 2012. CVD risk factors were defined using the modified Adult Treatment Panel III criteria for metabolic syndrome: (a) hypertension; (b) high-density lipoprotein cholesterol <= 40 mg/dL; (c) triglycerides >= 110 mg/dL; and (d) waist circumference (WC) >90th percentile. Prevalence of CVD risk factors, stratified by diagnosis year and diabetes type, was reported. Univariate and multivariate logistic models and Poisson regression were fit to estimate the prevalence trends for CVD risk factors individually and in clusters (>= 2 risk factors). Results The prevalence of >= 2 CVD risk factors was higher in youth with T2D than with T1D at each incident year, but the prevalence of >= 2 risk factors did not change across diagnosis years among T1D or T2D participants. The number of CVD risk factors did not change significantly in T1D participants, but increased at an annual rate of 1.38% in T2D participants. The prevalence of hypertension decreased in T1D participants, and high WC increased in T2D participants. Conclusion The increase in number of CVD risk factors including large WC among youth with T2D suggests a need for early intervention to address these CVD risk factors. Further study is needed to examine longitudinal associations between diabetes and CVD.
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