期刊
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
卷 36, 期 4, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ppsc.201800507
关键词
bioactive glass; bioactive nanoparticles; long-term biodegradation; long-term toxicity; surface functionalization
资金
- National Natural Science Foundation of China [51502237, 51872224, U1501245]
- China Postdoctoral Science Foundation [2017M613148]
- Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University [2018LHM-KFKT004]
Monodispersed bioactive glass nanoparticles (BGNs) have received much attention in various biomedical applications such as tissue regeneration, drug/gene delivery, bioimaging, and cancer therapy. However, the poor dispersion stability of BGNs in a physiological environment has limited their wide biomedical applications. The long-term in vitro/in vivo toxicity and biodegradation of BGNs are also not clear. Monodispersed glycerolphosphate-functionalized BGNs (GP-BGN) are synthesized and their stability under physiological environment in vitro, and long-term biodegradation behavior in vitro and in vivo are investigated herein. GP-BGN shows significantly enhanced particles stability in physiological environment, good hemocompatibility and cellular biocompatibility, as well as high cellular uptake ability. GP-BGN also exhibits long-term biodegradation behavior in vitro/in vivo and negligible biotoxicity (tissue and blood toxicity). This study demonstrates that monodispersed surface-functionalized BGNs could be used as biocompatible and biodegradable nanomaterials for long-term safe bioimaging and disease therapy.
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