期刊
PARASITES & VECTORS
卷 12, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13071-019-3393-z
关键词
Seresto (R); Imidacloprid; Flumethrin; Babesia canis; Dermacentor reticulatus; Transmission prevention
资金
- Bayer Animal Health
BackgroundAn imidacloprid/flumethrin collar (Seresto (R)) was previously shown to prevent infection with Babesia canis, transmitted by Dermacentor reticulatus, in dogs for up to 1 month after application. The present study evaluated the prevention of transmission throughout the claimed efficacy period of 8 months.MethodsEight animals each were randomly included in groups 1 (negative control) and 2 (Seresto (R) collar), respectively. Animals in group 2 received the Seresto (R) collar on Day 0. Tick challenges were performed monthly from the 2nd to the 8th month. Assessment criteria included in situ tick counts 48 hours post-challenge, polymerase chain reaction (PCR) analyses and immunofluorescence assays (IFA). Whenever dogs were diagnosed with babesiosis they were rescue-treated, excluded and replaced. Consequently, 24 replacement animals were introduced at various time points throughout the study in the control group; thus data for a total of 32 dogs were available in the latter group at study termination.ResultsAcaricidal efficacy for in situ counts was 93% on Day 30, and ranged from 97 to 100% thereafter. No B. canis specific DNA or antibodies were detected in any Seresto (R)-treated dog at any time. Babesia canis-specific DNA and antibodies were detected in 2-6 of 8 control dogs after each challenge, confirming the validity of the challenge model.ConclusionsThe Seresto (R) collar was highly effective against challenges with D. reticulatus ticks for up to 8 months. The high sustained acaricidal efficacy over this period prevented transmission of B. canis, thus fully protecting dogs against infection in this experimental infestation model.
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