期刊
ORGANOMETALLICS
卷 38, 期 4, 页码 973-980出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.organomet.8b00920
关键词
-
资金
- MINECO [CTQ2015-69568-P]
- Fundacion Seneca [19890/GERM/15]
- University of Toronto
- Alphora Research Inc.
- Natural Sciences and Engineering Research Council (NSERC)
- NSERC
- Collaborative Research and Training Experience (Create ChemNET) program
- Ministry of Science, Research and Technology of Iran
We report here a proof-of-concept for the cleavage of unstrained remote Csp(3)-Csp(3) bonds at room temperature assisted by a directing group, opening up new possibilities to use aliphatic carboxylic acids as suitable alkenyl coupling partners. This strategy involves the Pd-mediated Csp(3)-H activation directed by a tethered 8-aminoquinoline group, followed by a concerted asynchronous carbene insertion into the Pd-C bond, and an unexpected beta-carbon carbon bond splitting. The insertion of a coupling partner into a Pd-C bond is a novel route to promote C-C bond cleavage, which in contrast to most common methodologies does not rely on the use of strained carbocycles.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据