期刊
ANALYTICAL LETTERS
卷 49, 期 12, 页码 1847-1861出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/00032719.2015.1128946
关键词
Dopamine; functionalized graphene oxide; hydroxyethyl methacrylate; mass spectrometry; matrix-assisted laser desorption/ionization
资金
- National Natural Science Foundation of China [81173025, 21445007]
- Fundamental Research Funds for the Central Universities [201402049]
Dopamine is a neurotransmitter, whose concentration change causes various nervous system disorders such as Parkinson's disease. In this study, hydroxyethyl methacrylate-functionalized graphene oxide was prepared and used as the substrate for matrix-assisted laser desorption/ionization (MALDI) for the mass spectrometric determination of dopamine. The results show that hydroxyethyl methacrylate-functionalized graphene oxide materials may be used as a matrix for MALDI. This approach combines enrichment and detection in a single step. The new method greatly shortens the analysis time and significantly reduces the amount of sample required for the analysis. The detection limit of the method was 20 ng/mL. These features not only ensure that the method is suitable for trace analysis, but also extend the range of application of MALDI analysis to biochemical science.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据