期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 23, 期 4, 页码 648-653出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.oprd.8b00383
关键词
deuteration; arene; room temperature; platinum group metal; heterogeneous catalyst
资金
- Research Foundation for Pharmaceutical Sciences
- Japan Society for the Promotion of Science (JSPS) [16K08169]
- JSPS [15J01556]
- Grants-in-Aid for Scientific Research [15J01556, 16K08169] Funding Source: KAKEN
Arene nuclei efficiently underwent the hydrogen (H)-deuterium (D) exchange reaction catalyzed by platinum group metals on carbon in a mixed solvent of 2-propanol and D2O at room temperature to produce deuterium-labeled arenes. Platinum on carbon (Pt/C) and iridium on carbon (Ir/C) were applicable catalysts, and the various arenes bearing a carbonyl group, fluorine, phenolic hydroxy group, amino group, or phosphonic acid on the aromatic nucleus were effectively deuterated. Nonheating conditions are valuable for the scalable industrial preparation.
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