期刊
ORGANIC LETTERS
卷 21, 期 9, 页码 3067-3071出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b00652
关键词
-
资金
- DST-SERB [EMR/2016/003677]
- CSIR, New Delhi
An efficient tandem rhodium(II)/squaramide relay catalysis of readily accessible indole derivatives and N-sulfonyl-1,2,3-triazoles has been developed for the enantioselective synthesis of dihydro-beta-carbolines in good yield and enantioselectivity. The developed reaction involves selective insertion of in situ generated azavinyl rhodium carbene onto the C3-H bond of indole derivatives and subsequent squaramide-catalyzed enantioselective intramolecular aza-Michael reaction. Furthermore, the potential of the strategy was demonstrated through the ready conversion to potent tetrahydro-beta-carbolines and the tetracyclic alkaloid core structure.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据