期刊
ORGANIC LETTERS
卷 21, 期 7, 页码 2302-2306出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b00591
关键词
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资金
- Fundamental Research Funds for the Central Universities [lzujbky-2018-62]
- International Joint Research Centre for Green Catalysis and Synthesis, Gansu Provincial Sci. AMP
- Tech. Department [2016B01017, 18JR3RA284, 18JR4RA003]
- Lanzhou University
- E.B. Eddy endowment fund
N-Alkylation of indoles is one of the important pathways for the construction of various biologically active indole molecules. Using ketones as N-alkylation reagent for indoles has been a great challenge not only because of the competing alkylation reaction of C-3 position but also because of the poor nucleophilicity of the nitrogen atom of indole, in addition to the steric hindrance and lower electrophilicity of the ketones. A dearomatization-rearomatization strategy has been developed for reductive cross-coupling of indoles with ketones in water. Various functional groups and other heterocyclic compounds are tolerated.
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