期刊
ORGANIC LETTERS
卷 21, 期 7, 页码 2019-2024出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b00128
关键词
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资金
- National Natural Science Foundation of China [21801083, 21472053]
- Hubei Provincial Natural Science Foundation of China [0216013067]
A visible-light-enabled catalytic formylation of fluoroalkyl imines is developed. With readily accessible starting materials and organocatalysts, this method provides a general approach to masked fluoroalkyl amino aldehydes. A synergistic catalytic effect between the photosensitizer and the H atom transfer agent was proven pivotal to this transformation. After removing the mask, free aldehydes can be obtained and further converted to various beta-fluoroalkyl beta-amino alcohols, which are attractive building blocks in the synthesis of bioactive and pharmaceutical compounds.
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