期刊
ORGANIC LETTERS
卷 21, 期 6, 页码 1622-1626出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b00163
关键词
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资金
- National Institutes of Health, NCI [R01CA172310]
- Debbie and Sylvia DeSantis Chair professorship
- Shenzhen Peacock Plan [KQTD2015071714043444]
CXCR7 plays an emerging role in several physiological processes. A linear peptide, amantamide (1), was isolated from marine cyanobacteria, and the structure was determined by NMR and mass spectrometry. The total synthesis was achieved by solid-phase method. After screening two biological target libraries, 1 was identified as a selective CXCR7 agonist. The selective activation of CXCR7 by 1 could provide the basis for developing CXCR7-targeted therapeutics and deciphering the role of CXCR7 in different diseases.
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