期刊
ORGANIC LETTERS
卷 21, 期 5, 页码 1453-1457出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b00208
关键词
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资金
- China NSF [31870046, 41706169, 81425022, U1501223, U1706206]
- Guangdong NSF [2016A030312014, 2018A0303130005]
- CAS [YJKYYQ20170036]
- Special Support Program for Training High-Level Talents in Guangdong [201528018]
- Science and Technology Innovation Leader of Guangdong Province [2016TX03R095]
Genome mining of the deep sea-derived Streptomyces atratus SCSIO ZH16 enabled the activation of a cyclodepsipeptide gene cluster and isolation of its cinnamic acid-bearing product, atratumycin (1). Atratumycin's structure was elucidated on the basis of extensive spectroscopic experiments, X-ray data, and Marfey's method; a plausible biosynthesis and tailoring modification of 1 are also proposed and investigated. Additionally, atratumycin is active against Mycobacteria tuberculosis H37Ra and H37Rv with MICs of 3.8 and 14.6 mu M, respectively.
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