期刊
ORGANIC LETTERS
卷 21, 期 5, 页码 1551-1554出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b00475
关键词
-
资金
- Program for National Natural Science Foundation [21672087]
A pair of enantiomeric polyketides, (+)- and (-)-alternamgin (1), featuring an unprecedented 6/6/6/6/5/6/6 seven ring backbone, were isolated from the endophytic fungi Alternaria sp. MG1. The relative configuration of 1 was determined using X-ray diffraction, and the absolute configurations of (+/-)-1 were confirmed by comparing the experimental and calculated ECD data. Plausible biosynthetic pathways for 1 were proposed. Compound (-)-I exhibited moderate necrosis rates to Hela and HepG2 cells, but (+)-1 only showed similar necrosis rates to HepG2 cells.
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