期刊
ORGANIC LETTERS
卷 21, 期 5, 页码 1368-1373出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b00064
关键词
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资金
- Spanish Ministerio de Economia y Competitividad [CTQ2017-88171-P]
- Generalitat Valenciana [AICO/2017/007]
- Deutsche Forschungsgemeinschaft [GRK 1626, KO1537/18-1]
- Instituto de Sintesis Organica
An operationally simple method is disclosed for the decarboxylative cyanation of aliphatic carboxylic acids at room temperature. Riboflavin tetraacetate, which is an inexpensive organic photocatalyst, promotes the oxidation of carboxylic acids upon visible-light activation. After decarboxylation, the generated radicals are trapped by TsCN, yielding the desired nitriles without any further additive, in a redox-neutral process. Importantly, this protocol can be adapted to flow conditions.
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