期刊
ORGANIC LETTERS
卷 21, 期 4, 页码 1130-1133出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b00074
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资金
- National Program on Key Research Project [2016YFA0602900]
- National Natural Science Foundation of China [21702064, 21420102003]
- Pearl River S&T Nova Program of Guangzhou [201806010138]
- Guangdong Natural Science Foundation [2016A030310460]
The first defluorinative ipso-functionalization reaction of (trifluoromethyl)alkenes is reported. This exclusively regioselective ipso-defluorooxylation of (trifluoromethyl)alkenes with oximes affords various attractive O-(1,1-difluoroallyl)oxime ethers efficiently via a chemoselective single C(sp(3))-F bond activation in the CF3 group. Primary mechanism studies indicated an anionic S(N)2-type substitution pathway might be involved in this transformation.
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