期刊
ORGANIC LETTERS
卷 21, 期 4, 页码 1226-1231出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b00242
关键词
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资金
- NNSFC [21772208, 21702212, 21702182]
- NSFC of Jiangsu Province [BK20161260]
- Chinese Academy of Sciences
- Chinese Thousand Youth Talents Plan
- Fundamental Research Funds for the Central Universities
- Zhejiang University
A nickel-catalyzed Kumada coupling of aniline derivatives was developed by selective cleavage of aryl C-N bonds under mild reaction conditions. Without preinstallation of an ortho directing group on anilines, the cross-coupling reactions of Boc-protected aromatic amines with aryl Grignard reagents afforded unsymmetric biaryls. Mechanistic studies by DFT calculations revealed that the nickel-mediated C-N bond cleavage is the rate-limiting step.
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