期刊
ORGANIC LETTERS
卷 21, 期 4, 页码 1187-1190出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b00135
关键词
-
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [16H03285, 17H05450]
- Grants-in-Aid for Scientific Research [16H03285, 17H05450] Funding Source: KAKEN
Minnamide A is a lipopeptide with a unique repeating structure consisting of hydroxy and proposed beta-branched methyl groups. The absolute configuration of minnamide A was determined by a combination of chemical degradation, chiral HPLC analyses, and synthetic methods. Minnamide A showed growth-inhibitory activity toward HeLa cells with an IC50 value of 0.17 mu M and rapidly induced cell death at a concentration of 2 mu M. Minnamide A induced the copper-mediated accumulation of reactive oxygen species.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据