期刊
ANALYTICAL CHEMISTRY
卷 88, 期 13, 页码 6638-6647出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.6b01597
关键词
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资金
- DARPA under SSC Pacific Grant [HR0011-13-2-002]
- National Science Foundation under NSF MRSEC [DMR-1121262]
- Air Force Research Laboratory [FA8650-15-2-5518]
This perspective presents recent developments in the application of surface-enhanced Raman spectroscopy (SERS) to biosensing, with a focus on in vivo diagnostics. We describe the concepts and methodologies developed to date and the target analytes that can be detected. We also discuss how SERS has evolved from a point-and-shoot stand-alone technique in an analytical chemistry laboratory to an integrated quantitative analytical tool for multimodal imaging diagnostics. Finally, we offer a guide to the future of SERS in the context of clinical diagnostics.
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