期刊
ANALYTICAL CHEMISTRY
卷 88, 期 3, 页码 1526-1529出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.5b04758
关键词
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资金
- Toray Science Foundation
- JSPS Research Fellowships
- Grants-in-Aid for Scientific Research [25288079, 26670029] Funding Source: KAKEN
Mast cells secrete histamine upon degranulation triggered by various stimuli. Herein, we report the new detection method of mast cell degranulation using the fluorescent probe capable of detection of the released histamine. The probe was designed as the Co(II) complex of a cyanine dye, which shows a turn-on fluorescence signal based on a histamine-induced coordination displacement mechanism. Fluorescence imaging using the cell surface-anchored fluorescent probe enabled the real-time detection of mast cell degranulation induced by various secretagogues.
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