期刊
ANALYTICAL CHEMISTRY
卷 88, 期 21, 页码 10648-10653出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.6b03073
关键词
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资金
- National Natural Science Foundation of China [21472066, 21172086]
- Natural Science Foundation of Hubei Province [2014CFA042]
- Fundamental Research Funds for the Central Universities [CCNU16JCZX02]
Carbon monoxide (CO) is an important gasotransmitter in living systems and its fluorescent detection is of particular interest. However, fluorescent detection of CO in living cells is still challenging due to lack of effective probes. In this paper, a readily available fluorescein-based fluorescent probe was developed for rapid detection of CO. This probe can be used to detect CO in almost wholly aqueous solution under mild conditions and shows high selectivity and sensitivity for CO with colorimetric and remarkable fluorescent turn-on signal changes. The detection limit of this probe for CO is as low as 37 nM with a linear range of 0-30 mu M. More importantly, this probe (1 mu M dose) can be conveniently used for fluorescent imaging CO in living cells.
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