期刊
ANALYTICAL CHEMISTRY
卷 88, 期 10, 页码 5476-5481出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.6b00956
关键词
-
资金
- National Creative Research Initiative programs of the National Research Foundation of Korea (NRF) - Korean government (MSIP) [2012R1A3A2048814]
In this study, we developed a turn-on mitochondria-targeting hydrogen sulfide, probe 1, based on the selective thiolysis of 7-nitro-1,2,3-benzoxadiazole amine moiety attached to the piperazine-based naphthalimide scaffold. Probe 1 exhibited excellent properties with 68-fold fluorescence enhancement, a low detection limit (2.46 mu M), a low cytotoxicity, and a good selectivity toward hydrogen sulfide. The success of intracellular imaging indicated that probe 1 could be used in further applications for the investigation of biological functions and pathological roles of H2S in living systems.
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