期刊
ANALYTICAL CHEMISTRY
卷 88, 期 17, 页码 8714-8719出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.6b02054
关键词
-
资金
- U.S. Department of Energy [DE-AC52-07NA27344, R21GM111242]
- Research Resource for Biomedical AMS, Biomedical Technology Research Resources (BTRR) by the National Institutes of Health (NIH), National Institute of General Medical Sciences (NIGMS) [8P41GM103483]
A cavity ring-down spectroscopy (CRDS) instrument was developed using mature, robust hardware for the measurement of carbon-14 in biological studies. The system was characterized using carbon-14 elevated glucose samples and returned a linear response up to 387 times contemporary carbon-14 concentrations. Carbon-14 free and contemporary carbon-14 samples with varying carbon-13 concentrations were used to assess the method detection limit of approximately one-third contemporary carbon-14 levels. Sources of inaccuracies are presented and discussed, and the capability to measure carbon-14 in biological samples is demonstrated by comparing pharmacokinetics from carbon-14 dosed guinea pigs analyzed by both CRDS and accelerator mass spectrometry. The CRDS approach presented affords easy access to powerful carbon-14 tracer techniques that can characterize complex biochemical systems.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据