期刊
ANALYTICAL CHEMISTRY
卷 88, 期 11, 页码 5610-5614出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.6b01160
关键词
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资金
- National Natural Science Foundation of China [21402130, 81273471]
- National Program on Key Basic Research Project [2013CB734000]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT13028]
- Major Project of Science and Technology of Shandong Province [2015ZDJS04001]
- Shandong Key Research & Development Project [2015GSF118166]
- Fundamental Research Funds of Shandong University [2014JC008]
Nitroreductase (NTR) is an endogenous reductase overexpressed in hypoxic tumors; however, its precise detection in living cells and animals remains a considerable challenge. Herein, we developed three reaction based probes and a related bioluminescence assay for the real-time NTR detection. The high sensitivity and selectivity of probe 3, combined with its remarkable potential of bioluminescence imaging, affords a valuable approach for in vivo imaging of NTR in a tumor model mouse.
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