期刊
ANALYTICAL CHEMISTRY
卷 88, 期 10, 页码 5542-5548出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.6b01212
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资金
- Air Force Office of Scientific Research through Basic Research Initiative Grant [AFOSR FA9550-12-1-0400, FA9550-16-1-0113]
A method called nanotip ambient ionization mass spectrometry (NAIMS) is described, which applies high voltage between a tungsten nanotip and a metal plate to generate a plasma in which ionized analytes on the surface of the metal plate are directed to the inlet and analyzed by a mass spectrometer. The dependence of signal intensity is investigated as a function of the tip-to-plate distance, the tip size, the voltage applied at the tip, and the current. These parameters are separately optimized to achieve sensitivity or high spatial resolution. A partially observable Markov decision process is used to achieve a stabilized plasma as well as high ionization efficiency. As a proof of concept, the NAIMS technique has been applied to phenanthrene and caffeine samples for which the limits of detection were determined to be 0.14 fmol for phenanthrene and 4 amol for caffeine and to a printed caffeine pattern for which a spatial resolution of 8 +/- 2 mu m, and the best resolution of 5 mu m, was demonstrated. The limitations of NAIMS are also discussed.
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