期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 101, 期 -, 页码 1-12出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2019.03.017
关键词
Working memory; Attention; Neural networks; Hebblan plasticity; Attractor network
资金
- MRC Clinician Scientist Fellowship
- Wellcome Trust Principal Fellowship
- NIHR Oxford Biomedical Research Centre
- Wellcome Trust
- MRC [MR/P00878X/1] Funding Source: UKRI
Working memory, the ability to keep recently accessed information available for immediate manipulation, has been proposed to rely on two mechanisms that appear difficult to reconcile: self-sustained neural firing, or the opposite-activity-silent synaptic traces. Here we review and contrast models of these two mechanisms, and then show that both phenomena can co-exist within a unified system in which neurons hold information in both activity and synapses. Rapid plasticity in flexibly-coding neurons allows features to be bound together into objects, with an important emergent property being the focus of attention. One memory item is held by persistent activity in an attended or focused state, and is thus remembered better than other items. Other, previously attended items can remain in memory but in the background, encoded in activity-silent synaptic traces. This dual functional architecture provides a unified common mechanism accounting for a diversity of perplexing attention and memory effects that have been hitherto difficult to explain in a single theoretical framework.
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