期刊
NEUROPHARMACOLOGY
卷 151, 期 -, 页码 195-207出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2019.03.006
关键词
Opioids; Analgesics; Drug discovery; Tolerance; Nociceptin (NOP) receptor; Bifunctional activity
资金
- Concordia University Wisconsin
Prolonged treatment of chronic severe pain with opioid analgesics is frought with problematic adverse effects including tolerance, dependence, and life-threatening respiratory depression. Though these effects are mediated predominately through preferential activation of mu opioid peptide (mu OP) receptors, there is an emerging appreciation that actions at kappa OP and delta OP receptors contribute to the observed pharmacologic and behavioral profile of mu OP receptor agonists and may be targeted simultaneously to afford improved analgesic effects. Recent developments have also identified the related nociceptin opioid peptide (NOP) receptor as a key modulator of the effects of mu OP receptor signaling. We review here the available literature describing OP neurotransmitter systems and highlight recent drug and probe design strategies.
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