期刊
NEURON
卷 101, 期 6, 页码 1109-+出版社
CELL PRESS
DOI: 10.1016/j.neuron.2019.01.019
关键词
-
资金
- Wellcome Senior Investigator Award [WT100973AIA]
- MRC [MR/P024955/1, G0902373]
- Wellcome Trust Henry Dale Fellowship [105651/Z/14/Z]
- Wellcome Trust (UK) [105238/Z/14/Z]
- Wellcome Centre for Integrative Neuroimaging [203139/Z/16/Z]
- BBRSC [BB/N019814/1]
- NWO [452-13-015]
- Bettencourt Schueller Foundation
- Agence Nationale de la Recherche under the program Future Investments'' [ANR-10-EQPX-15]
- BBSRC [BB/N019814/1] Funding Source: UKRI
- MRC [G0600994, MR/P024955/1, G0902373] Funding Source: UKRI
The causal role of an area within a neural network can be determined by interfering with its activity and measuring the impact. Many current reversible manipulation techniques have limitations preventing their application, particularly in deep areas of the primate brain. Here, we demonstrate that a focused transcranial ultrasound stimulation (TUS) protocol impacts activity even in deep brain areas: a subcortical brain structure, the amygdala (experiment 1), and a deep cortical region, the anterior cingulate cortex (ACC, experiment 2), in macaques. TUS neuromodulatory effects were measured by examining relationships between activity in each area and the rest of the brain using functional magnetic resonance imaging (fMRI). In control conditions without sonication, activity in a given area is related to activity in interconnected regions, but such relationships are reduced after sonication, specifically for the targeted areas. Dissociable and focal effects on neural activity could not be explained by auditory confounds.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据