期刊
ANALYTICAL CHEMISTRY
卷 88, 期 14, 页码 7365-7371出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.6b01859
关键词
-
资金
- National Science Center (NCN Poland
- PRELUDIUM project) [UMO-2015/19/N/ST4/00379]
Renal cell carcinoma (RCC) accounts for several percent of all adult malignant tumor cases and is directly associated with over 120 thousand death cases worldwide annually. Therefore, there is a need for cancer biomarker tests and methods capable of discriminating between normal and malignant tissue. It is demonstrated that gold nanopartide enhanced target (AuNPET), a nano particle-based, surface-assisted laser desorption/ionization (SALDI)-type mass spectrometric method for analysis and imaging, can differentiate between normal and cancerous renal tissue. Diglyceride DG(18:1/20:0)-sodium adduct and protonated octadecanamide ions were found to have greatly elevated intensities in cancerous part of analyzed tissue specimen. Compounds responsible for mentioned ions formation were pointed out as a potential clear cell RCC biomarkers. Their biological properties and localization on the tissue surface are also discussed. Potential application of presented results may also facilitate clinical decision making during surgery for large renal masses.
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