期刊
NEUROBIOLOGY OF AGING
卷 74, 期 -, 页码 46-55出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2018.10.005
关键词
White matter lesion; Cardiovascular health; Blood pressure; Heart rate; Diffusion weighted imaging; Aging
资金
- UK Medical Research Council
- Biotechnology and Biological Sciences Research Council [BB/H008217/1]
- Wellcome Trust [103838]
- Sir Henry Wellcome Trust [107392/Z/15/Z]
- MRC Programme Grant [SUAG/014 RG91365]
- European Union [732592]
- Medical Research Council [MC_UP_1401/1] Funding Source: researchfish
- Wellcome Trust [107392/A/15/Z] Funding Source: researchfish
- BBSRC [BB/H008217/1] Funding Source: UKRI
- MRC [MC_UP_1401/1, MC_UU_00005/12, MC_UU_00005/9, MC_U105597119] Funding Source: UKRI
Cardiovascular health declines with age, increasing the risk of hypertension and elevated heart rate in middle and old age. Here, we used multivariate techniques to investigate the associations between cardiovascular health (diastolic blood pressure, systolic blood pressure, and heart rate) and white matter macrostructure (lesion volume and number) and microstructure (as measured by diffusion-weighted imaging) in the cross-sectional, population-based Cam-CAN cohort (N = 667, aged 18-88). We found that cardiovascular health and age made approximately similar contributions to white matter health and explained up to 56% of variance therein. Lower diastolic blood pressure, higher systolic blood pressure, and higher heart rate were each strongly, and independently, associated with white matter abnormalities on all indices. Body mass and exercise were associated with white matter health, both directly and indirectly via cardiovascular health. These results highlight the importance of cardiovascular risk factors for white matter health across the adult lifespan and suggest that systolic blood pressure, diastolic blood pressure, and heart rate affect white matter health via separate mechanisms. (C) 2018 The Authors. Published by Elsevier Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据