期刊
NATURE REVIEWS NEUROSCIENCE
卷 20, 期 5, 页码 282-297出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41583-019-0126-4
关键词
-
资金
- US National Institutes of Health [RO1-NS036692, RO1-NS082851, RO1-NS052634]
Epilepsy is a neurological disorder afflicting similar to 65 million people worldwide. It is caused by aberrant synchronized firing of populations of neurons primarily due to imbalance between excitatory and inhibitory neurotransmission. Hence, the historical focus of epilepsy research has been neurocentric. However, the past two decades have enjoyed an explosion of research into the role of glia in supporting and modulating neuronal activity, providing compelling evidence of glial involvement in the pathophysiology of epilepsy. The mechanisms by which glia, particularly astrocytes and microglia, may contribute to epilepsy and consequently could be harnessed therapeutically are discussed in this Review.
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