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Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers
Christian Behrends et al.
MOLECULAR CELL (2006)
Opposing activities protect against age-onset proteotoxicity
Ehud Cohen et al.
SCIENCE (2006)
Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins?
Hilal A. Lashuel et al.
QUARTERLY REVIEWS OF BIOPHYSICS (2006)
Progressive disruption of cellular protein folding in models of polyglutamine diseases
T Gidalevitz et al.
SCIENCE (2006)
Functional amyloid formation within mammalian tissue
DM Fowler et al.
PLOS BIOLOGY (2006)
Protein synthesis upon acute nutrient restriction relies on proteasome function
RM Vabulas et al.
SCIENCE (2005)
Small heat-shock proteins function in the insoluble protein complex
WW Jiao et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Heat shock protein 70 inhibits α-synuclein fibril formation via preferential binding to prefibrillar species
MM Dedmon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Cellular toxicity of polyglutamine expansion proteins: Mechanism of transcription factor deactivation
G Schaffar et al.
MOLECULAR CELL (2004)
Cooperation of molecular chaperones with the ubiquitin/proteasome system
C Esser et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2004)
Targeting expression of expanded polyglutamine proteins to the endoplasmic reticulum or mitochondria prevents their aggregation
E Rousseau et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
M Arrasate et al.
NATURE (2004)
Therapeutic approaches to protein-misfolding diseases
FE Cohen et al.
NATURE (2003)
Global analysis of protein expression in yeast
S Ghaemmaghami et al.
NATURE (2003)
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
R Kayed et al.
SCIENCE (2003)
Regulated cycling of mitochondrial Hsp70 at the protein import channel
QL Liu et al.
SCIENCE (2003)
Lifespan extension in C-elegans by a molecular chaperone dependent upon insulin-like signals
GA Walker et al.
AGING CELL (2003)
Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70
JC Young et al.
CELL (2003)
Rates of behavior and aging specified by mitochondrial function during development
A Dillin et al.
SCIENCE (2002)
Protofibrillar islet amyloid polypeptide permeabilizes synthetic vesicles by a pore-like mechanism that may be relevant to type II diabetes
M Anguiano et al.
BIOCHEMISTRY (2002)
Neurodegenerative disease - Amyloid pores from pathogenic mutations
HA Lashuel et al.
NATURE (2002)
Role of Escherichia coli curli operons in directing amyloid fiber formation
MR Chapman et al.
SCIENCE (2002)
Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease
PK Auluck et al.
SCIENCE (2002)
Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators
SJ Demarest et al.
NATURE (2002)
Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans
JL Feng et al.
DEVELOPMENTAL CELL (2001)
Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice
CJ Cummings et al.
HUMAN MOLECULAR GENETICS (2001)
Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease
A Sittler et al.
HUMAN MOLECULAR GENETICS (2001)
Impairment of the ubiquitin-proteasome system by protein aggregation
NF Bence et al.
SCIENCE (2001)
Aggresomes, inclusion bodies and protein aggregation
RR Kopito
TRENDS IN CELL BIOLOGY (2000)
Hsp70 and Hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils
PJ Muchowski et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
U Schubert et al.
NATURE (2000)
Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins
S Krobitsch et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease
A Yamamoto et al.
CELL (2000)
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