期刊
NATURE REVIEWS MICROBIOLOGY
卷 17, 期 4, 页码 203-218出版社
NATURE PORTFOLIO
DOI: 10.1038/s41579-018-0147-4
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资金
- Antibacterial Resistance Leadership Group fellowship (National Institute of Allergy and Infectious Diseases from the National Institutes of Health) [UM1AI104681]
- National Center for Advancing Translational Sciences of the National Institutes of Health [1KL2TR002554]
- National Institutes of Health [U01 AI-124319-01, 2R01-AI068804, K24-AI093969]
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most successful modern pathogens. The same organism that lives as a commensal and is transmitted in both health-care and community settings is also a leading cause of bacteraemia, endocarditis, skin and soft tissue infections, bone and joint infections and hospital-acquired infections. Genetically diverse, the epidemiology of MRSA is primarily characterized by the serial emergence of epidemic strains. Although its incidence has recently declined in some regions, MRSA still poses a formidable clinical threat, with persistently high morbidity and mortality. Successful treatment remains challenging and requires the evaluation of both novel antimicrobials and adjunctive aspects of care, such as infectious disease consultation, echocardiography and source control. In this Review, we provide an overview of basic and clinical MRSA research and summarize the expansive body of literature on the epidemiology, transmission, genetic diversity, evolution, surveillance and treatment of MRSA.
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