期刊
NATURE GENETICS
卷 51, 期 3, 页码 387-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41588-019-0361-7
关键词
-
资金
- NIH [R01DK107859, R21HL121728, F32DK102323, R01HL113338, R01DK102696, NHLBI R35 35HL135818, R01DK105072, T32HL007567, K01HL136884, HG003054]
- MGH Research Scholar Fund
- University of Manchester (Research Infrastructure Fund)
- Wellcome Trust
- UK Medical Research Council [MC_UU_12013/5, MC_UU_00011/6]
- UK National Institute of Health Research [NF-SI-0611-10196]
- European Research Council grant [SZ-245 50371-GLUCOSEGENES-FP7-IDEAS-ERC]
- Medical Research Council [MR/M005070/1]
- Wellcome Trust Institutional Strategic Support Award [WT097835MF]
- Stiftelsen Kristian Gerhard Jebsen
- Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU)
- Central Norway Regional Health Authority
- Liaison Committee for education, research and innovation in central Norway
- MRC [MC_UU_00011/5, MR/P012167/1, MR/P023576/2, MC_UU_12013/5] Funding Source: UKRI
Insomnia is a common disorder linked with adverse long-term medical and psychiatric outcomes. The underlying pathophysiological processes and causal relationships of insomnia with disease are poorly understood. Here we identified 57 loci for self-reported insomnia symptoms in the UK Biobank (n = 453,379) and confirmed their effects on self-reported insomnia symptoms in the HUNT Study (n = 14,923 cases and 47,610 controls), physician-diagnosed insomnia in the Partners Biobank (n = 2,217 cases and 14,240 controls), and accelerometer-derived measures of sleep efficiency and sleep duration in the UK Biobank (n = 83,726). Our results suggest enrichment of genes involved in ubiquitin-mediated proteolysis and of genes expressed in multiple brain regions, skeletal muscle, and adrenal glands. Evidence of shared genetic factors was found between frequent insomnia symptoms and restless legs syndrome, aging, and cardiometabolic, behavioral, psychiatric, and reproductive traits. Evidence was found for a possible causal link between insomnia symptoms and coronary artery disease, depressive symptoms, and subjective well-being.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据