期刊
NATURAL PRODUCT RESEARCH
卷 34, 期 9, 页码 1206-1212出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1553881
关键词
Mycophenolic acid derivative; Penicillium sp; antimicrobial
资金
- Chongqing Programs for Science and Technology Development [cstc2018jxjl-jbky0002]
- Chongqing Municipal Bureau of Health Science and technology of traditional Chinese medicine project [ZY20170380]
Mycophenolic acid (MPA) is a group of metabolite derived from several species of Penicillium, which shows potent bioactivity. In this study, a new derivative of MPA compound named penicacid D (1), was isolated from the marine derived fungus Penicillium sp. SCSIO sof101, along with seven known compounds (2-8). Their structures were elucidated based on the HR-ESI-MS and NMR data. Moreover, the H-1 and C-13 NMR data of compound 2 and the C-13 NMR data of compound 3 are reported. Compounds 1, 4 and 6 exhibited weak activities against Escherichia coli (clinical isolation number 100385570) and Acinetobacter baumannii (clinical isolation number 100069).
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