期刊
NATURAL PRODUCT RESEARCH
卷 34, 期 6, 页码 782-789出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1501689
关键词
Andrographolide derivatives; anti-inflammatory activity; egg white-induced rat paw edema model
资金
- National Natural Science Foundation of China [81373974]
- Henan Programs for Science and Technology Development [142300410370]
- Henan Science and Technology Development Plan Project [162102210176]
- Key Scientific and Technological Research Projects of Henan Education Department [15B350001]
Andrographolide is a main bioactive diterpene lactone in A. paniculata with anti-inflammatory activity. In this study, a series of andrographolide derivatives were synthesized and evaluated for their structure-anti-inflammatory activity relationships in vivo. Among all compounds, isoandrographolide and 14-deoxyandrographolide showed stronger anti-inflammatory activity than andrographolide. The results indicated that the introduction of tetrahydrofuran ring and cyclic olefinic bond plays an important role in enhancing the anti-inflammatory activity of andrographolide derivatives. Isoandrographolide and 14-deoxyandrographolide are potent inhibitor of inflammation. [GRAPHICS] .
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