Agaricus bisporus-derived β-glucan enter macrophages and adipocytes by CD36 receptor

beta-glucans are a heterogeneous group of natural polysaccharides. They are ubiquitously found in bacterial or fungal cell walls, cereals, seaweed, and mushrooms. The beneficial role of beta-glucan in tumor, insulin resistance, dyslipidemia, hypertension, and obesity is being continuously documented. Ample evidence showed that beta-glucan could act on several receptors, such as Dectin, complement receptor (CR3), TLR-2, 4, 6 and scavenger. Based on the above, we wanted to explore whether agaricus bisporus-derived beta-glucan acted on these receptors on Raw 264.7 macrophages and 3T3-L1 adipocytes.