期刊
NATURAL PRODUCT RESEARCH
卷 35, 期 4, 页码 587-592出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1587430
关键词
Lonicerae Japonicae Flos; lignan; anti-inflammatory activity; β -glucuronidase
A new lignan and three known compounds were isolated from Lonicerae Japonicae Flos, with one compound showing significant anti-inflammatory activity by inhibiting a specific release reaction.
One new lignan, loniceralanside A (1), together with three known compounds (2-4), were purified from Lonicerae Japonicae Flos. Their structures were determined by HR-ESI-MS, 1 D and 2 D NMR data. Compounds 2-4 were separated from the plant for the first time. The biological test showed that compound 1 had significant anti-inflammatory activity with inhibiting the release of beta-glucuronidase induced by platelet-activating factor (PAF) in rat polymorphonuclear leukocytes (PMNs) (IC50 = 3.05 mu M).
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