期刊
NANO LETTERS
卷 19, 期 5, 页码 2812-2823出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.8b04729
关键词
ischemic stroke; hollow Prussian blue; neuroprotection; nanozyme; reactive oxygen and nitrogen species
类别
资金
- National Natural Science Foundation of China (NSFC) [21788102, 81425015, 81725009]
- National Science Fund for Distinguished Young Scholars [81425014]
- Shanghai Youth Science and Technology Talents Project [18YF1419000]
- Shanghai Collaborative Innovation Center for Translational Medicine [TM201724]
- Shanghai Key Discipline of Medical Imaging [2017ZZ02005]
Ischemic stroke is a devastating disease and one of the leading causes of mortality worldwide. Overproduction of reactive oxygen and nitrogen species (RONS) following ischemic insult is known as a key factor in exacerbating brain damage. Thus, RONS scavengers that can block excessive production of RONS have great therapeutic potential. Herein, we propose an efficient treatment strategy in which an artificial nanozyme with multienzyme activity drives neuroprotection against ischemic stroke primarily by scavenging RONS. Specifically, through a facile, Bi3+-assisted, template-free synthetic strategy, we developed hollow Prussian blue nanozymes (HPBZs) with multienzyme activity to scavenge RONS in a rat model of ischemic stroke. The comprehensive characteristics of HPBZs against RONS were explored. Apart from attenuating oxidative stress, HPBZs also suppressed apoptosis and counteracted inflammation both in vitro and in vivo, thereby contributing to increased brain tolerance of ischemic injury with minimal side effects. This study provides a proof of concept for a novel class of neuroprotective nanoagents that might be beneficial for treatment of ischemic stroke and other RONS-related disorders.
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