期刊
NANO LETTERS
卷 19, 期 4, 页码 2272-2279出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.8b04677
关键词
Aggregation-induced emission (AIE); nanocarrier; siRNA; real-time; apoptosis
类别
资金
- Innovation and Technology Commission [ITC-CNERC14SC01, ITS/254117]
- National Science Foundation of China [NSFC 21788102]
- Research Grants Council of Hong Kong [16305015, N_HKUST604/14, A-HKUST605/16, C6009-17G]
- Science and Technology Plan of Shenzhen [JCYJ20160229205601482]
- [NSFC 1778009]
- [NSFC 81701818]
- [NSFC 21705111]
RNA interference (RNAi) is demonstrated as one of the most powerful technologies for sequence-specific suppression of genes in disease therapeutics. Exploration of novel vehicles for small interfering RNA (siRNA) delivery with high efficiency, low cytotoxicity, and self-monitoring functionality is persistently pursued. Herein, by taking advantage of aggregation-induced emission luminogen (AIEgen), we developed a novel class of Ag@AIE core@shell nanocarriers with regulable and uniform morphology. It presented excellent efficiencies in siRNA delivery, target gene knockdown, and cancer cell inhibition in vitro. What's more, an anticancer efficacy up to 75% was achieved in small animal experiments without obvious toxicity. Attributing to the unique AIE properties, real-time intracellular tracking of siRNA delivery and long-term tumor tissue imaging were successfully realized. Compared to the commercial transfection reagents, significant improvements were obtained in biocompatibility, delivery efficiency, and reproducibility, representing a promising future of this nanocarrier in RNAi-related cancer therapeutics.
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