Zn2+-Doped Carbon Dots, a Good Biocompatibility Nanomaterial Applied for Bio-Imaging and Inducing Osteoblastic Differentiation in vitro

Multifunctional photoluminescent (PL) nanomaterials have attracted considerable interest in terms of their potential applications in the field of clinical medicine. Carbon dots (CDs), as emerging optical nanomaterials, are promising in various fields including biological imaging, drug transport and nerve tracing. However, little research has investigated on bone tissue engineering as of now. In this study, a new kind of bifunctional Zn2+-doped carbon dots (Zn-CDs) has been synthesized by a one-step hydrothermal method, Zn-CDs show effective fluorescent imaging and induce osteoblastic differentiation abilities in vitro. Moreover, compared with the raw material, Zn-CDs exhibited more effective osteoblastic differentiation promoting capability. Overall, the biocompatible nanomaterial Zn-CDs show potential to be used as a promising novel nanodrug for bone loss therapy and also a monitor of cell variation by flourescence imaging.