期刊
MOLECULES
卷 24, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/molecules24061157
关键词
obesity; adipocyte differentiation; adipogenesis; natural products; 3T3-L1 preadipocytes
资金
- 2016 Yeungnam University Research Grant
Obesity is recognized as a worldwide health crisis. Obesity and its associated health complications such as diabetes, dyslipidemia, hypertension, and cardiovascular diseases impose a big social and economic burden. In an effort to identify safe, efficient, and long-term effective methods to treat obesity, various natural products with potential for inhibiting adipogenesis were revealed. This review aimed to discuss the molecular mechanisms underlying adipogenesis and the inhibitory effects of various phytochemicals, including those from natural sources, on the early stage of adipogenesis. We discuss key steps (proliferation and cell cycle) and their regulators (cell-cycle regulator, transcription factors, and intracellular signaling pathways) at the early stage of adipocyte differentiation as the mechanisms responsible for obesity.
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