期刊
MOLECULES
卷 24, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/molecules24061141
关键词
europium; fluorination; enantioselectivity; pybox; keto ester
资金
- Spain's MICINN [CTQ2014-53662-P]
- MEC [CTQ2016-81797-REDC]
- DURSI - Generalitat de Catalunya [2017 SGR 465]
A highly enantioselective catalytic method for the synthesis of quaternary alpha-fluoro derivatives of 3-oxo esters is described. The reaction uses europium (III) triflate and commercially available chiral pybox-type C2-symmetric ligand. Excellent results in terms of yields and enantioselectivities were assured using the electrophilic NFSI reagent under mild reaction conditions.
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