期刊
MOLECULES
卷 24, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/molecules24061080
关键词
pyrazole; 3; 5-diaminopyrazole; pyrazolo[1; 5-a]pyrimidine; microwave; antimicrobial; antitumor activities
资金
- King Abdulaziz City for Science and Technology
A new series of pyrazole 4-7 and pyrazolo[1,5-a]pyrimidine 8-13 were synthesized by using a simple, efficient procedure, and screened for their in-vitro antimicrobial and antitumor activities. Symmetrical and asymmetrical 3,6-diarylazo-2,5,7-triaminopyrazolo[1,5-a]pyrimidine were synthesized by the conventional method and also subjected to microwave irradiation and under ultrasound conditions. The biological results revealed that most of the tested compounds proved to be active as antibacterial and antifungal agents. The antitumor activity of the synthesized compounds was evaluated against human cancer cell lines, MCF-7, HCT-116, and HepG-2, as compared with Doxorubicin as a control.
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