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Cannabinoid Signaling in the Skin: Therapeutic Potential of the C(ut)annabinoid System

期刊

MOLECULES
卷 24, 期 5, 页码 -

出版社

MDPI
DOI: 10.3390/molecules24050918

关键词

acne; atopic dermatitis; cannabinoid; fibrosis; hair growth; inflammation; itch; psoriasis; skin; tumor; wound healing

资金

  1. National Research, Development and Innovation Office [120552, 121360, 125055, GINOP-2.3.2-15-2016-00015]
  2. EU's Horizon 2020 research and innovation program [739593]
  3. Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences
  4. Bolyai+ Scholarship of the New National Excellence Program of the Ministry of Human Capacities [UNKP-18-4-DE-247]
  5. Hungarian Ministry of Human Capacities [NTP-NFTO-18-B-0168]

向作者/读者索取更多资源

The endocannabinoid system (ECS) has lately been proven to be an important, multifaceted homeostatic regulator, which influences a wide-variety of physiological processes all over the body. Its members, the endocannabinoids (eCBs; e.g., anandamide), the eCB-responsive receptors (e.g., CB1, CB2), as well as the complex enzyme and transporter apparatus involved in the metabolism of the ligands were shown to be expressed in several tissues, including the skin. Although the best studied functions over the ECS are related to the central nervous system and to immune processes, experimental efforts over the last two decades have unambiguously confirmed that cutaneous cannabinoid (c[ut]annabinoid) signaling is deeply involved in the maintenance of skin homeostasis, barrier formation and regeneration, and its dysregulation was implicated to contribute to several highly prevalent diseases and disorders, e.g., atopic dermatitis, psoriasis, scleroderma, acne, hair growth and pigmentation disorders, keratin diseases, various tumors, and itch. The current review aims to give an overview of the available skin-relevant endo-and phytocannabinoid literature with a special emphasis on the putative translational potential, and to highlight promising future research directions as well as existing challenges.

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