期刊
MOLECULES
卷 24, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/molecules24050840
关键词
Scalarispongia; sesterterpenoid; furan; pyrrole; conjugate addition; cytotoxicity
资金
- Korea Institute of Ocean Science and Technology [PE99721]
- Korea Institute of Marine Science & Technology Promotion (KIMST) [PE99721] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Three furan-containing scalarane sesterterpenoids (1-3) and a novel pyrrole-containing analog (4) were isolated from the sponge Scalarispongia species. Compound 3, reported in the literature as a synthetic derivative of furoscalarol 2, was for the first time isolated from a natural source. During the separation performed using a silica column in the presence of methanol, 16-methoxy derivatives (5, 6) were obtained from the unintended reaction of 2. The isolated natural products 3 and 4 and the artifact 5 showed moderate to high cytotoxicity against six human cancer cell lines, whereas compound 6, the C-16 epimer of 5, showed no cytotoxicity at a concentration of 60 mu M.
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